以甲酰肽受体为模型开展对GPCR结构和功能的研究.
利用基因敲除等手段对炎症细胞活化过程中的关键信号传导分子和有关通路进行功能测定和分析，寻找新药靶点.
基于细胞水平的高通量药物筛选.
Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis.Lobel, P., Fujimoto, K., Ye, R.D., Griffiths, G., and Kornfeld, S..Cell.
Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3.Silverman, G.A., Ye, R.D., Pollock, K.M., Sadler, J.E., and Korsmeyer, S.J..Proc. Natl. Acad. Sci.
Platelet-activating factor induces NF-kB activation through a G protein-coupled pathway.Kravchenko, V.V., Pan, Z., Han, J., Ulevitch, R.J., and Ye, R.D..J. Biol. Chem.
Bradykinin stimulates NF-kB activation and interleukin-1beta gene expression in cultured human fibroblasts.Pan, Z., Zuraw, B.L., Lung, C.-C., Prossnitz, E.R., Browning, D.B., and Ye, R.D..J. Clin. Invest.
NF-kB activation is required for C5a-induced IL-8 gene expression in mononuclear cells.Hsu, M.H., Wang, M., Browning, D.D., Mukaida, N., and Ye, R.D..Blood.
Activation of NF-kB by bradykinin through a Gq and Gbeta/gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt.Xie, P., Browning, D.D., Hay, N., Mackman, N., and Ye, R.D..J. Biol. Chem..
Serum Amyloid A Induces IL-8 Secretion through a G protein-coupled Receptor, FPRL1/LXA4R.He, R., Sang, H., and Ye, R.D..Blood.
A stimulatory role for cGMP-dependent protein kinase in platelet activation.Li, Z., Xi, X., Gu, M., Feil, R., Ye, R.D., Eigenthaler, M., Hofmann, F., and Du, X.Cell.
Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G-proteins and the small GTPase Ras.Marty, C., Browning, D.D. and Ye, R.D..Mol. Cell. Biol..
Cutting Edge: TLR2 is a functional receptor for acute-phase serum amyloid A.Cheng, N., He, R.L., Tian, J., Ye, P.P. and Ye, R.D..J. Immunol.
Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2.He, R.L., Zhou, J., Hanson, C., Chen, J., Cheng, N., and Ye, R.D..Blood.
International Union of Pharmacology: Nomenclature for the formyl peptide receptor (FPR) family.Ye, R.D., Boulay, F., Wang, J.M., Dahlgren, C., Gerard, C., Parmentier, M., Serhan, C.N., and Murphy, P.M..Pharmacol.
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury.Feng Q, Deng J, Cheng N, Welch EJ, Zhang Y, Malik AB, Flavell RA, Dong C, Ye RD..EMBO J.
Akt isoforms differentially regulate neutrophil functions.Chen J, Tang H, Hay N, Xu J, Ye RD.Blood.
Heterotrimeric G protein signaling outside the realm of 7TM receptors (mini-revie w).Marty, C. and Ye, R.D..Mol. Pharmacol.
Biased agonism in chemoattractant signaling (editorial).Ye RD.J. Leuk. Biol.
