研究领域

模拟天然蛋白功能的合成高分子生物材料，包括：
1. 功能化聚合物单体的合成；多功能高分子材料的制备及合成方法研究
2. 生物相容、生物可降解高分子材料的研究与开发
3. 抗细菌、抗真菌生物材料的研制与作用机理研究
4. 具有细胞黏附、细胞选择功能的生物材料研究及在组织修复中的应用
5. 抗非特异性蛋白吸附及微生物生物膜形成的防污材料研究及在生物医学工程领域的应用
6. 蛋白类及小分子药物的体内传输和可控释放研究

论文

1. Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active Against Drug-Resistant Candida albicans Biofilms”, J. Am. Chem. Soc. 2015, 137：2183-2186.

2. Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc. 2014, 136: 4333–4342.

3. Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Gellman, S. H.; Masters, K. S. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc. 2014, 136: 4410-4418.

4. Liu, R.; Suárez, J. M.; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (Co-first author).

5. Chakraborty, S.; Liu, R.; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc. 2014, 136, 14530-14535. (Co-first author).

6. Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”, J. Am. Chem. Soc. 2013, 135: 16296-16299.

7. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273. (Featured in JACS Spotlights, J. Am. Chem. Soc. 2013, 135: 5933−5933).

8. Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.” J. Am. Chem. Soc. 2013, 135: 11748-11751.

9. Liu, R.; Vang, K. Z.; Kreeger, P. K.; Gellman, S. H.; Masters, K. S. “Experimental and Computational Analysis of Cellular Interactions with Nylon-3-Bearing Substrates.” Journal of Biomedical Materials Research Part A. 2012, 100: 2750-2759.

10. Liu, R.; Masters, K. S.; Gellman S. H. “Polymer Chain Length Effects on Fibroblast Attachment on Nylon-3-Modified Surfaces.” Biomacromolecules 2012, 13: 1100-1105.