研究领域

围绕多器官组织再生展开研究，在组织器官、细胞和基因水平揭示再生普遍规律，发现调控组织再生的关键基因，研究组织再生调控基因参与组织损伤、疾病、衰老的分子机理，为疾病的早期诊断、预防和治疗提供新的研究思路、新药靶点、基因工程新药、诊断技术和产品。

论文

1. IL-1Ra selectively protects intestinal crypt epithelial cells, but not tumor cells, from chemotoxicity via p53-mediated upregulation of p21WAF1and p27KIP1.X Wang, SY Zhu, L Qian, Jing Gao, MY Wu, J Gao,Y Zhang, Gerald L. Chanc, Y Yu, W Han.Pharmacological Research.

2. Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil.J Gao, J Gao, L Qian, X Wang, MY Wu, Y Zhang, H Ye, SY Zhu, Y Yu, W Han.Cancer Biology & Therapy.

3. Activated expression of the chemokine Mig following chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity.H Lu, S,Zhu L Qian, D Xiang, W Zhang, A Nie, J Gao, M Wu, J Gao, B,Lu Y Yu, W Han, Moldenhauer A.Blood.

4. Reg4 protects against acinar cell necrosis in experimental pancreatitis.GY Hu, JQ Shen, L Cheng, CY Guo, XF Xu, F Wang, L Huang, L Yang, M He, D Xiang, SY Zhu, MY Wu, Y Yu, W Han, XP Wang.Gut.

5. Interleukin 32 promotes hematopoietic progenitor expansion and attenuates bone marrow cytotoxicity.Moldenhauer A, Futschik M, Lu H, Helmig M, Götze P, Bal G, Zenke M, Han W, Salama A.Eur J Immunol.

6. Recombinant human midkine stimulates proliferation of articular chondrocytes.ZH Zhang, HX Li, YP Qi, LJ Du, SY Zhu, MY Wu, HL Lu, Y Yu, W Han.Cell Prolif.